There are currently around 33 million people worldwide living with HIV. Almost 2/3 of these are in sub-Saharan Africa where nearly 12 million children have been orphaned. But while huge progress has been made in some areas - including a decline in HIV-related deaths - the current epidemic cannot be reversed without reducing the rate of new HIV infections.
The search for the elusive vaccine continues, but for how long can we justify the millions being spent on this when we are apparently no nearer to finding a vaccine than we were 27 years ago when AIDS was first recognized?
We ask our panel of policy makers, scientists, journalists and community activists where they think the future lies for combating HIV and whether we really have seen the worst.